Mark Stein Selected Research

4- (2,5- difluorophenyl)- N- (3- fluoro- 1- methylpiperidin- 4- yl)- 2- (hydroxymethyl)- N- methyl- 2- phenyl- 2,5- dihydro- 1H- pyrrole- 1- carboxamide

6/2012

A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Mark Stein Research Topics

Disease

20	Neoplasms (Cancer) 01/2022 - 12/2008
14	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 12/2008
7	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 10/2013 - 03/2002
6	Primary Immunodeficiency Diseases 01/2022 - 03/2010
6	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 02/2011
4	Neoplasm Metastasis (Metastasis) 12/2021 - 04/2014
3	Disease Progression 02/2016 - 09/2009
2	Infections 01/2022 - 01/2016
2	Thrombocytopenia (Thrombopenia) 01/2017 - 12/2015
2	Fatigue 01/2017 - 09/2009
2	Hematologic Neoplasms (Hematological Malignancy) 11/2016 - 06/2015
1	Lymphoma (Lymphomas) 01/2017
1	Vomiting 01/2017
1	Erythema 01/2017
1	Nausea 01/2017
1	Reinfection 10/2016
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Bacterial Infections (Bacterial Infection) 01/2016
1	Hyperprolactinemia 01/2016
1	Measles 01/2016
1	Carcinogenesis 01/2016
1	Poliomyelitis (Polio) 01/2016
1	Neutropenia 12/2015
1	Sleepiness 10/2013
1	Neurobehavioral Manifestations 10/2013

Drug/Important Bio-Agent (IBA)

6	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 03/2010
4	Pharmaceutical PreparationsIBA 01/2017 - 06/2015
3	AndrogensIBA 12/2021 - 04/2012
3	Deoxyglucose (2 Deoxy D glucose)IBA 05/2012 - 12/2008
3	Methylphenidate (Ritalin)FDA LinkGeneric 06/2006 - 04/2003
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2019
2	IpilimumabIBA 01/2022 - 01/2020
2	NivolumabIBA 01/2022 - 01/2020
2	Sunitinib (Sutent)FDA Link 01/2021 - 02/2011
2	cabozantinibIBA 01/2021 - 01/2020
2	MTOR InhibitorsIBA 01/2019 - 01/2012
2	Everolimus FDA Link 01/2019 - 12/2015
2	TIC10 compoundIBA 01/2018 - 11/2016
2	Sorafenib (BAY 43-9006)FDA Link 01/2017 - 09/2009
2	Gemcitabine FDA Link 01/2017 - 01/2011
2	Docetaxel (Taxotere)FDA Link 02/2016 - 12/2015
2	Androgen Receptors (Androgen Receptor)IBA 02/2013 - 04/2012
2	Cisplatin (Platino)FDA LinkGeneric 01/2011 - 09/2009
1	B7-H1 AntigenIBA 01/2022
1	Hormones (Hormone)IBA 12/2021
1	Prostate-Specific Antigen (Semenogelase)IBA 12/2021
1	enzalutamideIBA 12/2021
1	CrizotinibIBA 01/2021
1	Proto-Oncogene Proteins c-metIBA 01/2021
1	1- (1- (imidazo(1,2- a)pyridin- 6- yl)ethyl)- 6- (1- methyl- 1H- pyrazol- 4- yl)- 1H- (1,2,3)triazolo(4,5- b)pyrazineIBA 01/2021
1	FluoridesIBA 01/2020
1	Aurora Kinase AIBA 01/2019
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2019
1	MLN 8237IBA 01/2019
1	Capsules (Microcapsules)IBA 01/2018
1	XL765IBA 01/2018
1	Immune Checkpoint InhibitorsIBA 01/2018
1	Antineoplastic Agents (Antineoplastics)IBA 01/2018
1	ChromatinIBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	TabletsIBA 01/2018
1	Formaldehyde (Formol)FDA Link 01/2018
1	Histones (Histone)IBA 01/2018
1	ParaffinIBA 01/2018
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2018
1	plitidepsin (aplidine)IBA 01/2017
1	DepsipeptidesIBA 01/2017
1	Alanine Transaminase (SGPT)IBA 01/2017
1	LigandsIBA 11/2016
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 02/2016
1	STA 9090IBA 02/2016
1	Adenosine Triphosphatases (ATPase)IBA 02/2016
1	Monoclonal AntibodiesIBA 01/2016
1	Prolactin Receptors (Prolactin Receptor)IBA 01/2016
1	ProlactinIBA 01/2016
1	AntibodiesIBA 01/2016
1	Neutralizing AntibodiesIBA 01/2016
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2016
1	Carboplatin (JM8)FDA LinkGeneric 12/2015
1	Prednisone (Sone)FDA LinkGeneric 12/2015
1	Metformin (Glucophage)FDA LinkGeneric 06/2015
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 06/2015
1	Axl Receptor Tyrosine KinaseIBA 06/2015
1	Neurotransmitter Agents (Neurotransmitter)IBA 10/2013
1	Lapatinib (GW572016)FDA Link 02/2013
1	Biological ProductsIBA 02/2013
1	Epidermal Growth Factor (EGF)IBA 02/2013
1	AMPA Receptors (AMPA Receptor)IBA 12/2012
1	Org 26576IBA 12/2012
1	Glutamic Acid (Glutamate)FDA Link 12/2012
1	ABT-737IBA 09/2012
1	KinesinsIBA 06/2012
1	4- (2,5- difluorophenyl)- N- (3- fluoro- 1- methylpiperidin- 4- yl)- 2- (hydroxymethyl)- N- methyl- 2- phenyl- 2,5- dihydro- 1H- pyrrole- 1- carboxamideIBA 06/2012
1	Proteins (Proteins, Gene)FDA Link 06/2012

Therapy/Procedure

13	Therapeutics 12/2021 - 12/2008
4	Drug Therapy (Chemotherapy) 12/2015 - 09/2009
3	Castration 01/2019 - 12/2015
2	Radiotherapy 12/2021 - 04/2014
2	Prostatectomy (Retropubic Prostatectomy) 12/2021 - 04/2014
1	Immunotherapy 09/2021